Opportunity Information: Apply for RFA HL 20 025
The Heart, Lung, and Blood Co-morbiditieS Implementation Models in People Living with HIV (HLB SIMPLe) funding opportunity (RFA HL 20 025) is a National Institutes of Health cooperative agreement program designed to improve how proven, effective interventions for heart, lung, blood, and sleep (HLBS) comorbidities are actually delivered to people living with HIV (PLHIV) in low-resource settings. Rather than funding early discovery or testing whether an intervention works, this announcement focuses on the real-world problem that many interventions already known to be effective do not consistently reach patients or are not sustained over time within routine HIV care systems. The overall goal is to generate practical, scalable implementation approaches that strengthen prevention and treatment for HLBS conditions alongside HIV care and that can be sustained in everyday clinical, public health, and community-based environments.
A central feature of the FOA is its emphasis on late-stage implementation research, described here as research aimed at identifying strategies that drive durable uptake and long-term integration of evidence-based interventions. In practical terms, applicants are expected to study how to close the gap between evidence and routine practice by testing implementation strategies that improve adoption, fidelity, reach, quality, and sustainability of HLBS comorbidity services for PLHIV. The intent is to maximize population health impact, meaning projects should be designed with an eye toward outcomes that matter at scale, not just within a small pilot clinic. Although the research is conducted in World Bank-designated low- and middle-income countries (LMICs) and Small Island Developing States (SIDS), the program explicitly seeks results that can generalize to low-resource settings globally.
Projects funded through this FOA must be conducted in one or more of the specified world regions: East Asia and the Pacific, Europe and Central Asia, Latin America and the Caribbean, Middle East and North Africa, South Asia, and Sub-Saharan Africa. Beyond individual projects, NIH intends for the funded investigators to function as a collaborative alliance focused on T4 (late-stage) implementation research for HLBS comorbidities in PLHIV across LMICs. That alliance concept signals that awardees may be expected to coordinate on shared learning, cross-site comparisons, and complementary research questions that together build a stronger evidence base than any single study could provide.
The mechanism is a two-phase, milestone-driven UG3/UH3 cooperative agreement, which means NIH will have substantial programmatic involvement and the transition from the first phase to the second depends on meeting pre-specified milestones. The UG3 phase (about 1 to 2 years) supports study start-up and needs assessment activities, such as partnership building, refining workflows, assessing barriers and facilitators, tailoring implementation strategies to local contexts, finalizing protocols, and preparing sites and staff. If UG3 milestones are met, the project can transition into the UH3 phase (about 3 to 4 years), where the main implementation research is carried out, typically involving the active rollout and evaluation of strategies intended to improve delivery and sustainability of the proven interventions within real service systems. The maximum total project period is 5 years.
Eligibility is broad and includes many types of U.S. entities (state, county, and local governments; special district governments; independent school districts; public housing authorities/Indian housing authorities; public and private institutions of higher education; nonprofits with or without 501(c)(3) status; for-profit organizations other than small businesses; and small businesses). Importantly, foreign institutions are eligible and explicitly encouraged, reflecting the fact that the research is intended to be led or co-led by teams with deep on-the-ground expertise in LMIC and SIDS contexts. The FOA is categorized under health and uses a cooperative agreement funding instrument, aligning with the milestone-based, partner-style relationship NIH often uses for complex, multi-site, implementation-focused programs.
From a funding and scale standpoint, the opportunity listed an award ceiling of $690,000 and anticipated making about 7 awards. The announcement was created on October 2, 2019, with an original closing date of December 10, 2019, and it is administered under the U.S. Department of Health and Human Services, National Institutes of Health. The FOA also notes that clinical trials are optional, which gives applicants flexibility to propose rigorous evaluation designs that may or may not meet NIHs formal definition of a clinical trial, depending on whether the study prospectively assigns participants to interventions or strategies and measures health-related outcomes.
Overall, the HLB SIMPLe FOA is aimed at moving beyond knowing what works to knowing how to make what works actually happen at scale for PLHIV who also face substantial risks from cardiovascular, pulmonary, hematologic, and sleep-related conditions. It prioritizes sustainable delivery models, context-appropriate implementation strategies, and collaborative learning across diverse LMIC and SIDS regions, with the expectation that the knowledge gained will be useful for strengthening integrated HIV and noncommunicable disease care in low-resource settings worldwide.Apply for RFA HL 20 025
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Heart, Lung, and Blood Co-morbiditieS Implementation Models in People Living with HIV (HLB SIMPLe) (UG3/UH3 - Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233, 93.837, 93.838, 93.839, 93.840, 93.989.
- This funding opportunity was created on Oct 02, 2019.
- Applicants must submit their applications by Dec 10, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $690,000.00 in funding.
- The number of recipients for this funding is limited to 7 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Public housing authorities/Indian housing authorities, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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