Opportunity Information: Apply for PAR 17 207
The National Institutes of Health (NIH) funding opportunity titled "Alliance of Glycobiologists for Cancer Research: Biological Tumor Glycomics Laboratories (U01)" (Funding Opportunity Number PAR-17-207) supports cooperative agreement projects that investigate how and why glycosylation changes during cancer development. The central scientific focus is on mechanisms: applicants are expected to study the biological processes that drive alterations in glycosylation and other carbohydrate-structure modifications as cells undergo oncogenesis and as tumors progress through different stages of disease. A key motivation behind the program is to move the field beyond observation and correlation by determining whether specific glycan changes are contributing causes of malignant transformation, downstream consequences of transformation, or part of a feedback loop that sustains tumor growth, invasion, immune evasion, or metastasis. In other words, the FOA is positioned to fund research that can clarify the direction of causality and the functional significance of tumor-associated glycan remodeling.
The FOA is designed for team-based science that deliberately combines complementary expertise in glycobiology and cancer biology. Because glycosylation is regulated by complex networks (including glycosyltransferases, glycosidases, nucleotide-sugar metabolism, glycan transport, and the cellular context that determines protein and lipid glycosylation), the NIH is explicitly encouraging research groups that can connect mechanistic glycobiology to cancer-relevant phenotypes and models. Projects under this initiative are expected to examine how modifications in carbohydrate structure influence malignancy across stages of disease, which can include early transformation events, tumor growth and progression, interactions with the tumor microenvironment, dissemination, and metastatic colonization. The "Biological Tumor Glycomics Laboratories" framing also signals an emphasis on biologically grounded glycomics work rather than purely descriptive profiling, with an expectation that glycan changes will be tied to mechanisms and functional outcomes in cancer systems.
From an administrative and funding standpoint, this is a discretionary NIH opportunity using the Cooperative Agreement mechanism (U01). The cooperative agreement structure generally implies substantial NIH programmatic involvement compared with a standard research grant, often including coordination across funded teams and shared goals under a broader research alliance. The activity areas are listed under Education and Health, and the associated CFDA numbers are 93.393, 93.394, and 93.396. The opportunity was created on 2017-03-08, and the original closing date listed is 2019-02-07. The source data indicates an award ceiling of $500,000; the number of expected awards is not specified in the provided record.
Eligibility is broad and includes many types of domestic institutions and organizations, reflecting NIH's intent to attract a wide range of capable research teams. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations and tribal governments that are not federally recognized; public housing authorities and Indian housing authorities; nonprofit organizations with and without 501(c)(3) status (excluding institutions of higher education in those categories as specified); for-profit organizations other than small businesses; small businesses; and other entities. The FOA also explicitly calls out additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and non-domestic (non-U.S.) entities (foreign organizations). This wide eligibility list is consistent with a program that aims to build a collaborative research ecosystem and accelerate progress in understanding how tumor glycosylation changes shape cancer biology.
In practical terms, a competitive application under this FOA would be expected to propose a mechanistically driven cancer glycobiology project, clearly articulate how glycosylation changes will be linked to oncogenic processes, and demonstrate a team structure that bridges deep glycan expertise with strong cancer biology, models, and translational relevance. The overall intent is to generate knowledge that can explain the biological role of altered tumor glycosylation, helping clarify whether these changes initiate or reinforce cancer behavior and potentially pointing toward new intervention strategies, biomarkers, or therapeutic concepts grounded in glycan biology.Apply for PAR 17 207
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Alliance of Glycobiologists for Cancer Research: Biological Tumor Glycomics Laboratories (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.394, 93.396.
- This funding opportunity was created on 2017-03-08.
- Applicants must submit their applications by 2019-02-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the title of this NIH funding opportunity?
The funding opportunity is titled "Alliance of Glycobiologists for Cancer Research: Biological Tumor Glycomics Laboratories (U01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PAR-17-207.
What type of NIH funding mechanism is used?
This opportunity uses a Cooperative Agreement mechanism (U01), which typically involves substantial NIH programmatic involvement compared with a standard research grant.
What is the central scientific focus of the FOA?
The central focus is to investigate how and why glycosylation changes during cancer development, with an emphasis on mechanisms that drive alterations in glycosylation and other carbohydrate-structure modifications during oncogenesis and tumor progression.
What kinds of research questions is NIH trying to answer through this program?
The FOA is positioned to move the field beyond observation and correlation by determining whether specific glycan changes are contributing causes of malignant transformation, downstream consequences of transformation, or part of feedback loops that sustain tumor growth, invasion, immune evasion, or metastasis.
Does the FOA prioritize mechanistic studies over descriptive profiling?
Yes. The "Biological Tumor Glycomics Laboratories" framing signals an emphasis on biologically grounded glycomics work rather than purely descriptive profiling, with an expectation that glycan changes will be tied to mechanisms and functional outcomes in cancer systems.
What cancer stages or processes can be studied under this initiative?
Projects are expected to examine how carbohydrate-structure modifications influence malignancy across stages of disease, which can include early transformation events, tumor growth and progression, interactions with the tumor microenvironment, dissemination, and metastatic colonization.
What kinds of biological drivers of glycosylation changes are mentioned as relevant?
The FOA highlights that glycosylation is regulated by complex networks, including glycosyltransferases, glycosidases, nucleotide-sugar metabolism, glycan transport, and the cellular context that determines protein and lipid glycosylation.
Is this opportunity intended for team-based science?
Yes. The FOA is designed for team-based science that deliberately combines complementary expertise in glycobiology and cancer biology, encouraging research groups that can connect mechanistic glycobiology to cancer-relevant phenotypes and models.
What does "cooperative agreement" imply for how NIH will interact with awardees?
Based on the description provided, the cooperative agreement structure generally implies substantial NIH programmatic involvement, often including coordination across funded teams and shared goals under a broader research alliance.
What are the activity areas associated with this funding opportunity?
The activity areas listed are Education and Health.
What CFDA numbers are associated with this opportunity?
The associated CFDA numbers are 93.393, 93.394, and 93.396.
When was this opportunity created?
The opportunity was created on 2017-03-08.
What is the listed closing date for the opportunity?
The original closing date listed is 2019-02-07.
What is the award ceiling for this FOA?
The source data indicates an award ceiling of $500,000.
Is the expected number of awards specified?
No. The number of expected awards is not specified in the provided record.
Who is eligible to apply?
Eligibility is broad and includes many types of institutions and organizations. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations and tribal governments that are not federally recognized; public housing authorities and Indian housing authorities; nonprofit organizations with and without 501(c)(3) status (excluding institutions of higher education in those categories as specified); for-profit organizations other than small businesses; small businesses; and other entities.
Are minority-serving institutions explicitly eligible?
Yes. The FOA explicitly calls out Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, HBCUs, and TCCUs as eligible applicant categories.
Are U.S. territories or possessions eligible to apply?
Yes. U.S. territories or possessions are explicitly included in the eligible applicant categories.
Are non-U.S. (foreign) organizations eligible?
Yes. The FOA explicitly includes non-domestic (non-U.S.) entities (foreign organizations) as eligible.
Are for-profit entities eligible?
Yes. For-profit organizations other than small businesses are listed as eligible, and small businesses are also listed as eligible.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly listed among additional eligible applicant categories.
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are explicitly included in the eligible applicant categories.
What would a competitive application be expected to emphasize?
A competitive application would be expected to propose a mechanistically driven cancer glycobiology project, clearly articulate how glycosylation changes will be linked to oncogenic processes, and demonstrate a team structure that bridges deep glycan expertise with strong cancer biology, models, and translational relevance.
What kinds of outcomes or impacts is the FOA trying to enable?
The overall intent is to generate knowledge explaining the biological role of altered tumor glycosylation, clarify whether glycan changes initiate or reinforce cancer behavior, and potentially point toward new intervention strategies, biomarkers, or therapeutic concepts grounded in glycan biology.
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Applicants also applied for:
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| Mechanisms of Alcohol-associated Cancers (R21) Apply for PA 17 219 Funding Number: PA 17 219 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Mechanisms of Alcohol-associated Cancers (R01) Apply for PA 17 220 Funding Number: PA 17 220 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Revision Applications to National Cancer Institute (NCI)-supported U01 Awards to Include Research on the NCI's Provocative Questions (U01) Apply for RFA CA 17 020 Funding Number: RFA CA 17 020 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revision Applications to National Cancer Institute (NCI)-supported P01 Awards to Include Research on the NCI's Provocative Questions (P01) Apply for RFA CA 17 021 Funding Number: RFA CA 17 021 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revision Applications to National Cancer Institute (NCI)-supported P50 Awards to Include Research on the NCI's Provocative Questions (P50) Apply for RFA CA 17 022 Funding Number: RFA CA 17 022 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revision Applications to NCI-supported R01 Awards to Include Research on the NCI's Provocative Questions (R01) Apply for RFA CA 17 019 Funding Number: RFA CA 17 019 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Supplements for Validating the Use of Automated Sources of Residential Histories in Cancer Epidemiology Cohorts (Admin Supp) Apply for PA 17 222 Funding Number: PA 17 222 Agency: National Institutes of Health Category: Education, Health Funding Amount: $125,000 |
| Research Supplements to Promote Sharing Data in Cancer Epidemiology Studies (Admin Supp) Apply for PA 17 224 Funding Number: PA 17 224 Agency: National Institutes of Health Category: Education, Health Funding Amount: $100,000 |
| Supplement Opportunity to Support Population-Based Research Studies of Rare Cancers (Admin Supp) Apply for PA 17 223 Funding Number: PA 17 223 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Advancing the Science of Geriatric Palliative Care (R01) Apply for PA 17 225 Funding Number: PA 17 225 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Advancing the Science of Geriatric Palliative Care (R21) Apply for PA 17 226 Funding Number: PA 17 226 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Core Infrastructure and Methodological Research for Cancer Epidemiology Cohorts (U01) Apply for PAR 17 233 Funding Number: PAR 17 233 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,250,000 |
| Mechanisms and Consequences of Sleep Disparities in the U.S. (R21) Apply for PAR 17 235 Funding Number: PAR 17 235 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Innovative Research in Cancer Nanotechnology (IRCN) (R01) Apply for PAR 17 240 Funding Number: PAR 17 240 Agency: National Institutes of Health Category: Education, Health Funding Amount: $450,000 |
| Mechanisms and Consequences of Sleep Disparities in the U.S. (R01) Apply for PAR 17 234 Funding Number: PAR 17 234 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Fostering Research Training and Education Programs for Native American Students at NCI-designated Cancer Centers (Admin Supp) Apply for PA 17 241 Funding Number: PA 17 241 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Avenir Award Program for Research on Substance Abuse and HIV/AIDS (DP2) Apply for RFA DA 18 004 Funding Number: RFA DA 18 004 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Secondary Analysis and Integration of Existing Data to Elucidate the Genetic Architecture of Cancer Risk and Related Outcomes (R21) Apply for PA 17 243 Funding Number: PA 17 243 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Secondary Analysis and Integration of Existing Data to Elucidate the Genetic Architecture of Cancer Risk and Related Outcomes (R01) Apply for PA 17 239 Funding Number: PA 17 239 Agency: National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| Activities to Promote Research Collaborations on Immune-Related Adverse Events (APRC-irAEs) Associated with Cancer Immunotherapy (Admin Supp) Apply for PA 17 248 Funding Number: PA 17 248 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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