Opportunity Information: Apply for HT9425 23 DMDRP TRA
The DoD Duchenne Muscular Dystrophy Translational Research Award (FY23 DMDRP TRA; Funding Opportunity Number HT9425-23-DMDRP-TRA) is a Department of Defense funding mechanism designed to push advanced Duchenne muscular dystrophy (DMD) projects toward real clinical use. The program is run through the U.S. Army Medical Research Acquisition Activity (USAMRAA) under CFDA 12.420, and it supports work that sits squarely in translational research, meaning it intentionally blends basic science with clinical insights. The emphasis is not just on taking lab findings into humans, but on maintaining a two-way exchange where clinical realities shape lab experiments and lab results loop back to inform clinical development. In other words, the award is meant for research that actively connects what is happening in patients with the mechanistic and developmental work needed to build interventions that can actually be tested and adopted.
This opportunity is specifically aimed at established projects that have already moved beyond early-stage basic research and simple proof-of-concept. The expectation is that applicants are proposing mature, well-supported efforts with a credible pathway to near-term impact in clinical research or clinical care. Projects can include pilot or proof-of-principle clinical trials, as well as correlative and supportive studies that strengthen the development of drugs, devices, or other interventions. A key eligibility requirement in the application itself is that every proposal must include preliminary data directly relevant to DMD and the proposed approach, reinforcing that this mechanism is not intended for brand-new, untested ideas without supporting evidence.
A notable scientific priority embedded in the description is the encouragement of therapies and interventions that can be effective across the full DMD lifespan. The call explicitly highlights the need to consider populations that are often challenging to study or treat, including infants and toddlers, as well as individuals who are non-ambulatory. This signals that the program values translational strategies that are not narrowly limited to one disease stage, and that aim to be broadly applicable to the diverse clinical realities of DMD progression.
The award also includes an Early-Career Partnering PI Option intended to build capacity in the DMD research field by promoting serious, productive collaboration. Under this structure, two principal investigators can formally share leadership: an Initiating PI, who handles most administrative responsibilities for submission, and an Early-Career Partnering PI, who is expected to make substantial intellectual and practical contributions to the project. Both investigators are expected to participate meaningfully in core components such as the Project Narrative and the Statement of Work, rather than treating the early-career role as a minor add-on. If funded, each PI is named on an individual award within the recipient organization, reflecting a formal commitment to shared leadership and career development.
From an administrative standpoint, the opportunity is listed as discretionary and uses either a grant or cooperative agreement funding instrument. Eligibility is described as unrestricted (open to any type of entity), subject to any clarifications that may appear in the full announcement. The posting indicates an expected two awards. The opportunity was created on June 6, 2023, with an original closing date of August 23, 2023. The listed award ceiling appears as zero in the source data, which typically signals that the ceiling is not specified in that field rather than implying that no funding is available, and applicants would normally confirm budget limits and expectations in the full funding announcement and associated program guidance.
Overall, the DMDRP Translational Research Award is positioned as a late preclinical to early clinical bridge for DMD, supporting research that is already grounded in data, tightly aligned with patient-centered clinical needs, and structured to move an intervention, tool, or actionable insight toward clinical testing and adoption, ideally with feedback loops between the clinic and the lab to keep the work both scientifically rigorous and clinically relevant.Apply for HT9425 23 DMDRP TRA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Duchenne Muscular Dystrophy Translational Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Jun 06, 2023.
- Applicants must submit their applications by Aug 23, 2023. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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