Priority HIV/AIDS Research within the Mission of NIDDK (R01 Clinical Trial Optional) | PAS 24 163

Opportunity Information: Apply for PAS 24 163

Priority HIV/AIDS Research within the Mission of NIDDK (R01 Clinical Trial Optional) (Funding Opportunity Number: PAS-24-163) is an NIH discretionary grant opportunity designed to expand and strengthen HIV/AIDS research that fits squarely within the scientific and public health mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The purpose is not to fund HIV research in general, but to stimulate studies that connect HIV/AIDS to the specific disease areas NIDDK oversees, including diabetes, endocrinology and metabolism, digestive diseases, nutrition, obesity, liver and biliary diseases, and kidney, urologic, and hematologic conditions. Projects are expected to align with the broader, NIH-wide HIV/AIDS research priorities established by the NIH Office of AIDS Research (OAR), as described in the NIH guidance document referenced in the announcement (NOT-OD-20-018, which outlines HIV/AIDS research priorities and how NIH determines whether projects qualify as HIV/AIDS research for funding considerations).

The mechanism is an R01, meaning it supports investigator-initiated, hypothesis-driven research projects that typically involve a clear scientific premise, strong preliminary rationale (when appropriate), and a well-developed plan of approach. The opportunity is labeled "Clinical Trial Optional," which signals that applicants may propose either clinical trial research or non-clinical trial research, as long as the project fits the NOFO scope and NIH rules. In practice, that means an application could range from basic, translational, or clinical investigations, including studies that address how HIV infection, antiretroviral therapy, co-infections, inflammation, or immune dysfunction affect NIDDK-relevant organ systems and outcomes. It also leaves room for research that improves prevention, diagnosis, treatment, and long-term management of HIV-associated comorbidities that fall within NIDDK domains (for example, kidney disease in people with HIV, metabolic complications associated with HIV and its therapies, gastrointestinal and liver complications, or nutritional and endocrine impacts).

This funding opportunity sits under the Health and Food and Nutrition activity category and is associated with CFDA number 93.847. The sponsoring agency is the National Institutes of Health. The announcement lists an original closing date of January 7, 2025. While the source data does not specify an award ceiling or the expected number of awards, applicants should generally anticipate standard NIH R01 budgeting and review expectations, including strong justification of costs, rigorous methods, and appropriate protections for human subjects when applicable.

Eligibility is broad and reflects NIH’s intent to encourage participation across many types of organizations. Eligible applicants include a wide range of U.S. governmental entities (state, county, city/township, and special district governments), federally recognized Native American tribal governments, public housing authorities/Indian housing authorities, independent school districts, and public or state-controlled institutions of higher education. The opportunity also allows applications from private institutions of higher education, nonprofit organizations (both 501(c)(3) and non-501(c)(3) entities), for-profit organizations other than small businesses, and small businesses. In addition, the NOFO explicitly highlights other eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). It also includes faith-based and community-based organizations, eligible federal agencies, U.S. territories or possessions, regional organizations, and non-domestic (non-U.S.) entities/foreign organizations, as well as Indian/Native American tribal governments that are not federally recognized.

Overall, PAS-24-163 is best understood as a targeted R01 pathway for HIV/AIDS research proposals that advance NIH’s HIV priorities while directly contributing to NIDDK’s core interests in metabolic, digestive, nutritional, kidney, urologic, liver, and related diseases. Competitive applications will typically make the NIDDK relevance explicit, show clear alignment with OAR priority areas, and present a rigorous research strategy that can meaningfully improve understanding or management of HIV-associated conditions within NIDDK’s scientific and clinical scope.

• The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Priority HIV/AIDS Research within the Mission of NIDDK (R01 Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
• This funding opportunity was created on 2024-02-29.
• Applicants must submit their applications by 2025-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAS 24 163

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