Research Project Grant (Parent R01 Clinical Trial Not Allowed) | PA 19 056

Opportunity Information: Apply for PA 19 056

The National Institutes of Health (NIH) Research Project Grant (Parent R01, Clinical Trial Not Allowed), funding opportunity number PA 19 056, is a discretionary grant mechanism designed to support a clearly defined, focused research project proposed by an investigator or team of investigators. The R01 is NIH's primary funding vehicle for investigator-initiated research and is intended for projects that are discrete and well-bounded in scope, with specific aims, a planned approach, and a rationale that aligns with the scientific priorities of one or more participating NIH Institutes and Centers (ICs). In practice, that means applicants are expected to frame their work around a research question that fits within an NIH institute's mission area and can be evaluated through the standard NIH peer review process for significance, innovation, approach, investigators, and research environment.

A key restriction in this particular announcement is that it does not accept applications that propose clinical trials. Applicants need to ensure their proposed work does not meet NIH's definition of a clinical trial, which generally involves prospective assignment of human participants to an intervention with the goal of evaluating effects on health-related biomedical or behavioral outcomes. Studies that involve humans may still be possible depending on the design (for example, certain observational or basic mechanistic studies), but proposals cannot include a clinical trial component under this FOA. For projects that do include clinical trials, NIH typically directs applicants to use a different FOA specifically allowing or requiring clinical trial applications.

Eligibility is broad and includes many types of organizations that commonly conduct research or support research infrastructure. Domestic eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations other than federally recognized tribal governments; public housing authorities/Indian housing authorities; and nonprofit organizations both with and without 501(c)(3) status (as long as they are not institutions of higher education, since those are listed separately). The FOA also allows for-profit organizations (other than small businesses) and small businesses, reflecting NIH's openness to funding meritorious research across sectors when the scientific case is strong and the organization can manage federal grant requirements.

In addition to the standard categories above, the announcement explicitly highlights other eligible applicant types, emphasizing inclusivity across institutional forms and geographies. These include Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); and Tribally Controlled Colleges and Universities (TCCUs). It also includes faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-domestic (non-U.S.) entities such as foreign organizations, which can apply when permitted by NIH policies and when the project offers unique scientific opportunities or resources that justify foreign participation.

Programmatically, this R01 parent announcement spans a wide range of NIH-related topic areas and aligns with multiple CFDA listings (including numerous 93.xxx programs), which signals that many NIH Institutes and Centers participate and that the scientific scope is intentionally broad. Applicants are expected to select an NIH institute alignment and craft a proposal that speaks directly to that institute's interests, including the public health relevance and the way the research will advance knowledge in the targeted field. While the source data does not specify an award ceiling or number of expected awards, R01 budgets and project periods are typically driven by scientific need and NIH policy, with final funding decisions based on peer review outcomes, program priorities, and available appropriations.

The opportunity is administered by NIH, with the source listing showing an original closing date of 2020-05-24 and a creation date of 2018-11-05. For planning purposes, applicants should treat the R01 parent announcement as a structured pathway to propose investigator-initiated research, but they still need to confirm current submission dates, participating institutes, and any updated policy requirements in the active NIH posting for PA 19 056 (or its successor), especially because NIH parent announcements are periodically reissued and updated.

• The National Institutes of Health in the education, environment, food and nutrition, health, income security and social services sector is offering a public funding opportunity titled "Research Project Grant (Parent R01 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.172, 93.213, 93.233, 93.242, 93.273, 93.279, 93.286, 93.307, 93.351, 93.361, 93.393, 93.394, 93.396, 93.399, 93.837, 93.838, 93.839, 93.840, 93.846, 93.847, 93.853, 93.855, 93.859, 93.865, 93.866, 93.879.
• This funding opportunity was created on 2018-11-05.
• Applicants must submit their applications by 2020-05-24. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PA 19 056

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