Opportunity Information: Apply for RFA DA 24 022

This NIH funding opportunity (RFA-DA-24-022) supports a cooperative agreement (U24, clinical trial optional) to build a patient-centered research resource center aimed at advancing the federal Ending the HIV Epidemic effort for people who are involved in the criminal legal system. The central purpose is to create a Patient Engagement Resource Center (PERC) that strengthens and accelerates the work of the HIV/Justice Regional Research Hubs (referenced as being funded under RFA-DA-24-105) by supplying practical, scalable ways to bring the perspectives of affected communities directly into research planning and implementation. The emphasis is not just on producing research outputs, but on creating durable infrastructure, tools, and consultation capacity that multiple hub projects can use.

At the core of the project is a partnership model grounded in lived experience. The PERC is expected to collaborate with patients and other stakeholders who have direct experience with HIV, substance use disorders (SUD), and the criminal legal system. In practice, that means setting up a research advisory and consultation approach that can guide hub investigators on how to design studies, interventions, recruitment strategies, consent processes, retention plans, and dissemination activities in ways that are credible and usable for justice-involved populations. The opportunity highlights user-centered design as the overarching philosophy, signaling that the resource center should rely on structured feedback loops, co-design methods, and iterative testing rather than top-down program design.

Beyond consultation and engagement infrastructure, the awardee is also expected to carry out original research. That research component focuses on identifying major barriers that prevent justice-involved individuals from accessing and using HIV and SUD prevention and treatment services, and then pilot testing potential solutions to address those barriers. The intent is applied: identify what blocks care in real settings (during incarceration, at reentry, while on probation/parole, or in community supervision contexts) and test practical strategies that could improve uptake and continuity of HIV and SUD services. The combined center-and-research structure is meant to inform both research and practice, so findings and tools can be translated into how the hubs run their projects and, ideally, how systems deliver care.

Administratively, this is a discretionary NIH opportunity under CFDA 93.279, using a cooperative agreement mechanism, which typically means substantial NIH involvement in program stewardship compared to a standard grant. The listed award ceiling is $350,000, and the original closing date shown is August 16, 2023. While the opportunity references clinical trials as optional, applicants would still need to align any proposed human subjects activities with NIH policies and the specific requirements associated with U24 awards.

Eligibility is broad and includes many types of domestic organizations: state, county, and local governments; special districts; public housing authorities; independent school districts; public and private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; nonprofits with and without 501(c)(3) status; for-profit organizations (other than small businesses) as well as small businesses; and other eligible entities. The announcement also calls out additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, Hispanic-serving institutions, historically Black colleges and universities, tribally controlled colleges and universities, eligible federal agencies, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. Foreign institutions are not eligible to apply, and non-U.S. components of U.S. organizations are not eligible; however, foreign components are allowed as defined under the NIH Grants Policy Statement, which generally means limited foreign involvement can be included when it is well-justified and compliant with NIH policy.

Overall, the grant is designed for an applicant that can function as a national-level support and coordination resource for multiple regional hub projects, while also generating new evidence about how to reduce real-world barriers to HIV and SUD services for people impacted by incarceration and related legal system involvement. The throughline is meaningful patient and lived-experience engagement, structured in a way that consistently improves how research and interventions are designed, tested, and ultimately adopted in justice-related settings.

  • The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Ending the HIV Epidemic: Resource Center to Engage Justice-Involved Populations (U24 Clinical Trial Optional)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
  • This funding opportunity was created on 2023-04-19.
  • Applicants must submit their applications by 2023-08-16. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $350,000.00 in funding.
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
Apply for RFA DA 24 022

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FAQs: NIH RFA-DA-24-022 Patient Engagement Resource Center (PERC)

What is this funding opportunity (RFA-DA-24-022) about?

This NIH funding opportunity supports a cooperative agreement (U24, clinical trial optional) to build a Patient Engagement Resource Center (PERC) focused on advancing the federal Ending the HIV Epidemic effort for people involved in the criminal legal system. The main aim is to create practical, scalable engagement infrastructure that helps ensure research is designed and carried out in ways that reflect the needs and realities of justice-involved populations.

What is the PERC expected to do?

The PERC is expected to function as a patient-centered support and coordination resource. It should supply tools, infrastructure, and consultation capacity that can be used across multiple projects, especially the HIV/Justice Regional Research Hubs referenced as funded under RFA-DA-24-105. The focus is on durable resources and processes that improve how research is planned, implemented, and shared.

How does this opportunity relate to the HIV/Justice Regional Research Hubs?

The PERC is intended to strengthen and accelerate the work of the HIV/Justice Regional Research Hubs by providing practical ways to incorporate the perspectives of affected communities into hub research planning and implementation. In other words, the PERC supports the hubs by offering engagement methods, consultation, and reusable resources that hub investigators can apply across multiple studies and settings.

Is the emphasis on producing research outputs or building infrastructure?

The emphasis is not only on traditional research outputs. A central expectation is building durable infrastructure, tools, and consultation capacity that multiple hub projects can reuse. The intent is to create practical, scalable resources that improve real-world research design and delivery for justice-involved populations.

What does "patient-centered" mean in the context of this opportunity?

Patient-centered here means grounding the resource center in lived experience and ensuring that people directly affected by HIV, substance use disorders (SUD), and the criminal legal system meaningfully shape how research is designed and carried out. This includes incorporating community perspectives into recruitment, consent, retention, intervention design, and dissemination in ways that are credible and usable for justice-involved populations.

Who are the key stakeholders the PERC should partner with?

The PERC is expected to collaborate with patients and other stakeholders who have direct experience with HIV, SUD, and the criminal legal system. The partnership model is explicitly grounded in lived experience to ensure research approaches fit real settings and real constraints.

What kind of engagement and consultation activities are expected?

The opportunity describes a research advisory and consultation approach that helps guide hub investigators on practical matters such as study and intervention design, recruitment strategies, consent processes, retention plans, and dissemination activities. The goal is to help investigators design research that is workable, trusted, and relevant for justice-involved communities.

What is meant by "user-centered design" in this announcement?

User-centered design is described as an overarching philosophy for the PERC. It suggests the center should rely on structured feedback loops, co-design methods, and iterative testing rather than top-down program design. The idea is to build tools and processes with the people who will be affected by and use them, refining approaches based on real feedback.

Does the award require the PERC to conduct original research?

Yes. Beyond engagement infrastructure and consultation support, the awardee is also expected to carry out original research aimed at identifying major barriers that prevent justice-involved individuals from accessing and using HIV and SUD prevention and treatment services, and then pilot testing potential solutions to address those barriers.

What is the focus of the research component?

The research is applied and focuses on real-world barriers that block access to HIV and SUD prevention and treatment. It also involves pilot testing strategies intended to improve uptake and continuity of services across settings such as during incarceration, at reentry, or within probation/parole and community supervision contexts.

Which settings and points of contact are highlighted for understanding barriers to care?

The opportunity highlights several real-world contexts where barriers may occur: during incarceration, at reentry, while on probation or parole, and in community supervision contexts. The intent is to identify what blocks care across these touchpoints and test practical strategies to improve continuity and service use.

How are the tools and findings expected to be used?

The combined center-and-research structure is meant to inform both research and practice. The expectation is that tools, consultation approaches, and research findings can be translated into how the hubs run their projects and, ideally, how systems deliver HIV and SUD services for justice-involved individuals.

What funding mechanism is being used?

This opportunity uses a cooperative agreement mechanism (U24). Cooperative agreements typically involve substantial NIH involvement in program stewardship compared to a standard grant.

Are clinical trials allowed under this opportunity?

Clinical trials are described as optional. Applicants would still need to ensure any proposed human subjects activities align with NIH policies and the specific requirements associated with U24 awards.

What is the award ceiling for this opportunity?

The listed award ceiling is $350,000.

What is the CFDA number associated with this opportunity?

The opportunity is listed under CFDA 93.279.

What is the closing date listed for this opportunity?

The original closing date shown is August 16, 2023.

Who is eligible to apply?

Eligibility is broad and includes many types of domestic organizations, including state, county, and local governments; special districts; public housing authorities; independent school districts; public and private institutions of higher education; federally recognized Native American tribal governments and other Native American tribal organizations; nonprofits with and without 501(c)(3) status; for-profit organizations (other than small businesses); small businesses; and other eligible entities.

Are there specific categories of institutions and organizations called out as eligible?

Yes. The announcement also specifically calls out Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, Hispanic-serving institutions, historically Black colleges and universities, tribally controlled colleges and universities, eligible federal agencies, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions.

Are foreign institutions eligible to apply?

No. Foreign institutions are not eligible to apply.

Can a U.S. organization include a non-U.S. component on the application?

No. Non-U.S. components of U.S. organizations are not eligible.

Are foreign components allowed at all?

Foreign components are allowed as defined under the NIH Grants Policy Statement. This generally means limited foreign involvement can be included when it is well-justified and compliant with NIH policy, even though foreign institutions and non-U.S. components are not eligible to apply.

What kind of applicant is this opportunity designed for?

The grant is designed for an applicant that can function as a national-level support and coordination resource for multiple regional hub projects, while also generating new evidence about reducing barriers to HIV and SUD services for people impacted by incarceration and related legal system involvement.

What is the central "throughline" of the opportunity?

The central throughline is meaningful patient and lived-experience engagement, structured to consistently improve how research and interventions are designed, tested, and shared in justice-related settings.

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