Opportunity Information: Apply for RFA AG 24 035

The Limited Competition: The Harmonized Cognitive Assessment Protocol (HCAP) Network (U24 Clinical Trial Not Allowed) funding opportunity (RFA-AG-24-035) is a National Institutes of Health (NIH) cooperative agreement designed to keep a major research network and its supporting infrastructure running and growing. The focus is a high-priority area in behavioral and social research on Alzheimers disease (AD) and AD-related dementias (ADRD), specifically through the HCAP International AD/ADRD Research Network. In practical terms, the award is meant less for launching a single stand-alone research project and more for sustaining and expanding a coordinated international platform that helps researchers collect, harmonize, compare, and interpret cognitive assessment data across studies, countries, languages, and populations.

The core purpose is network and infrastructure-building. The NOFO emphasizes activities that help the field move faster and more consistently by strengthening shared methods and shared resources. Supported activities can include convening meetings that bring investigators together to define new research directions, align priorities, and collaborate on the development of network infrastructure. It also includes small-scale pilot efforts to test, adapt, or tailor cognitive or related measures for use in new populations or settings, which is often necessary when tools developed in one context need to be validated or adjusted for different cultures, education levels, languages, or field conditions.

Another major component is producing practical guidance for the broader research community on topics that commonly create bottlenecks or inconsistencies across dementia studies. The NOFO specifically calls out guidance related to biomarkers, diagnosis and classification of dementia, protocol development, fieldwork challenges, statistical harmonization, and analytic methods. This reflects a key problem in AD/ADRD research: even when studies ask similar questions, differences in how cognition is measured, how dementia is classified, and how data are processed can make results hard to compare. By funding structured guidance and harmonization work, NIH is supporting a shared backbone that improves cross-study comparability and the usefulness of pooled or comparative analyses.

Training and education are also clearly within scope. The opportunity allows educational activities such as intensive summer institutes, workshop series and other network events, or advanced seminars focused on methodology. These training efforts are meant to spread best practices, build capacity among early-career and mid-career researchers, and ensure that the specialized skills needed for high-quality cognitive assessment, harmonization, and analysis are more widely available. Alongside training, the NOFO expects dissemination and outreach, meaning the network should actively share outputs such as protocols, recommendations, harmonization strategies, and lessons learned with the larger AD/ADRD research ecosystem, not just with network insiders.

Coordination is a stated expectation as well. The HCAP network is expected to connect and align with other related AD/ADRD networks, which helps prevent duplication of effort and encourages compatible standards. Because it is a cooperative agreement (U24), the NIH typically plays an active role in the project, with substantial programmatic involvement compared with a standard grant. The "Clinical Trial Not Allowed" designation means the award cannot be used to support a clinical trial as defined by NIH policy; the emphasis is on infrastructure, methods, and network activities rather than testing an intervention in human participants.

Eligibility is broad and includes many organization types: state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized governments; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations (other than small businesses); and small businesses. The NOFO also highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, non-domestic (non-U.S.) entities, and eligible federal agencies. This broad eligibility aligns with the network-building goal, encouraging participation from institutions and communities that can expand the reach and relevance of harmonized cognitive assessment work.

Key administrative details from the source include an original closing date of 2023-11-01, an award ceiling of $385,000, and an indicated expected awards field that is not specified in the provided text. The assistance listing is associated with CFDA 93.866, and the activity category is health. Overall, the NOFO is best understood as support for the connective tissue of AD/ADRD behavioral and social research: maintaining and advancing a global, harmonized approach to cognitive assessment, developing shared guidance and methods, training researchers, piloting measurement improvements, and coordinating across related efforts so data and findings can be compared and combined more reliably across diverse studies and populations.

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition: The Harmonized Cognitive Assessment Protocol (HCAP) Network (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
  • This funding opportunity was created on 2023-09-06.
  • Applicants must submit their applications by 2023-11-01. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $385,000.00 in funding.
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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